Opioids are widely used for treating different types of pains, but overuse and abuse of prescription opioids have led to opioid epidemic in the United States. This database was constructed to facilitate finding novel targets and small molecular compounds for treating opioid abuse and dependence.
In this database, you can find targets (differentially expressed genes and transcription regulators) activated in mouse striatum after mice were exposed to morphine or heroin for a briefly period of time, as well as potential small molecular compounds that can mitigate the effects of the targets.
The content in this database is based on our findings in: A computational strategy for finding novel targets and therapeutic compounds for opioid dependence, bioRxiv MS: 359075 .
The Database is constructed for academic research purposes. None of the information or resources provided shall be construed as constituting medical advice. If you are seeking medical or treatment advice, please seek the attention of a qualified health care provider.